Endocrine Abstracts

Introduction: The demand of cortisol rises during stress and to avoid acute cortisol deficiency, patients undergoing transsphenoidal surgery at Skåne University Hospital (Sweden) receive peri- and postoperative substitution with hydrocortisone (HC), even at normal ACTH function. Some anesthetics are known to affect cortisol levels.This study aimed to assess the perioperative cortisol plasma levels during transsphenoidal surgery in ACTH sufficient an...

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

Introduction: The morbidity of craniopharyngioma (CP) includes cognitive dysfunction with attention deficits, impaired episodic memory and processing speed (Fjalldal et al., 2013) and CP patients with hypothalamic damage are more affected. fMRI is a technique used to investigate cortical activity by detecting alterations in blood flow in response to stimuli or actions. Previously pre- and post-meal fMRI responses to visual food cues were investigated showing higher ac...

Background: Hypothalamic damage caused by craniopharyngioma (CP) is related to memory deficits, disturbed attention, and impaired processing speed. This is the first study that aims to establish a structure to function relationship by assessing cognitive function in adult patients with childhood-onset (CO) CP along with volumetric analysis of the hypothalamus.Method: Forty-one (24 women) surgically treated CO-CP patients (median age at diagnosis; 11 year...

Introduction: Adult patients with craniopharyngioma (CP) and hypothalamic (HT) damage have impaired cognitive function. The white matter (WM) changes behind these findings remain to be elucidated. Diffusion tensor imaging (DTI) is a MRI technique that quantifies microstructural damage in the WM. This is the first study of DTI, hippocampal (HC) and HT volume in relation to cognition in CP patients.Methods: A cross-sectional study of childhood onset CP was...

Background/objectives: Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor Craniopharyngioma (CP). Attempts have been made to predict the risk of HO based on hypothalamic (HT) damage on magnetic resonance imaging (MRI), but none have included volumetry. Qualitative and quantitative (volumetric) analyses of HT damage was performed. The results were explored in relation to feeding related peptides and body fat.Subjects/methods: A c...